A Ba/Pd Catalytic System Enables Dehydrative Cross-Coupling and Excellent E-selective Wittig Reactions

Peizhong Xie^*1, Weishan Fu¹, Xinying Cai¹, Zuolian Sun¹, Ying Wu¹, Shuangshuang Li¹, Cuiqing Gao², Xiaobo Yang¹, and Teck-Peng Loh^*1,3

¹School of Chemistry and Molecular Engineering, Institute of Advanced Synthesis, Nanjing Tech University, Nanjing 211816, P. R. China.

²Southern Modern Forestry Collaborative Innovation Center, College of Forestry, Nanjing Forestry University, Nanjing, 210037, China

³Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.

Abstract:ABa/Pd cooperative catalysis system was developed to enable the dehydrative cross-coupling of allylic alcohols with P-ylidesto occurdirectly andpromote asubsequent Wittig reaction in one pot. A variety of multisubstituted 1,4-dienes were isolated in good to excellent yields with broad P-ylides (both ester and ketone carbonyl group stabilized) and aldehyde (aliphatic and aromatic) substrates with excellentE-selectivity.

Org. Lett,2019,21, 7055-7059（2019影响因子：6.555）

论文链接：https://pubs.acs.org/doi/abs/10.1021/acs.orglett.9b02623