Site-selective C(sp³)–H amination of thioamidewith anthranils under Cp*Co^IIIcatalysis

Rui-Hua Liu,^aQi-Chao Shan,^aXu-Hong Hu*^aand Teck-Peng Loh*^ab

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^bDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Abstract:Synthetically versatile anthranils as a bifunctional amino sourcehave been employed for the first time to enable direct amination onunactivated C(sp³)–H bonds of thioamides under Cp*Co^IIIcatalysis.The excellent site-selectivity on primary C(sp³)–H bonds is observedfor a diverse array of thioamideswith high functional group tolerance.Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.

Chem. Commun.2019,55, 5519-5522(2017年影响因子：6.29)

论文链接：https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc01715a#!divAbstract