Photoredox-Coupled F-Nucleophilic-Addition-Induced Allylation ofgem-Difluoroalkenes

Haidong Liu, Liang Ge, Ding-Xing Wang, Nan Chen, and Chao Feng*

Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 210009, P. R. of China

Abstract:A novel strategy for the expedient construction of CF₃-embeded tertiary/quarternary carbon centers was developed by taking advantage of photoredox catalysis. Thanks to a key step of single-electron oxidation, electron-rich gemdifluoroalkenes, which otherwise are essentially reluctant towards F-nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation, as well as functionalization, ofα-CF₃-substituted benzylic radical intermediates using cheap and readily available starting materials.

Angew. Chem. Int. Ed.DOI: 10.1002/anie.201814308 (2018年影响因子: 12.102).

论文链接：https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201814308