Polycyclic heteroaromatic ring construction driven by silver/cobalt co-catalyzed desulfonylative and defluorinative fragment-recombination of enol nonaflates with amidines

Ting Xie,^aYao-Wei Zhang,^aLi-Li Liu,^aZhi-Liang Shen,^aTeck-Peng Loh,^*a,band Xue-Qiang Chu^*a

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China

^bDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

Abstract:We present a Ag(I)/Co(II) co-catalyzed tandem fragmentation and recombination reaction commencing from detachable nonaflates and amidines. This catalytic method offers a unique and expeditious access to various fluoroalkylated dihydrobenzo[h]quinazolines and benzo[h]quinazolines in the absence of external fluorine sources through a rationally designed radical desulfonylation, migration, defluorination, and polar condensation relay.

Chem. Commun.,2018,54, 12722-12725.(2017年影响因子：6.29;论文第一作者为二年级研究生谢婷)。

论文链接：https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc07409g#!divAbstract。