Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides

Yao Zhao,^aJiacheng Rui,^aQiang Du,^aRizhi Chen,^bYing Zhan,^aXintao Zheng,^aXiaojin Wu^*a

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering,Nanjing Tech University, Nanjing 211816, China.

^bState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing TechUniversity, Nanjing 211816, China

Abstract:A general catalytic base-controlled regiodivergent nucleophilichydrofunctionalization of both terminal and internal β,γ-unsaturated amides has been reported. The atom-economicaladdition of various S/P-based nucleophiles was also exclusivelychemoselective. More than 60 branched or linear heterosubstituted aliphatic amides were synthesized from commonstarting materials under transition-metal-free conditions.Preliminary mechanistic studies are consistent with our proposeddivergent catalytic cycles.

Chem. Commun.DOI: 10.1039/D1CC03440E (IF = 6.222)

文章链接：https://doi.org/10.1039/D1CC03440E