王可，博士后

研究方向：

1.主要从事天然产物纯化、合成、结构修饰及活性研究

2.抗肿瘤药物的设计、合成、结构修饰及活性研究

3.癌症进程中的肿瘤微环境与脂质组分变化的关系

教育背景：

2010.09-2016.06中国药科大学药物化学系硕博连读

2006.09-2010.07中国药科大学药学系学士

工作经历：

2025.03至今博士后新利18彩票 药学院

2016.09-2023.07访问学者中国医药大学（台湾）

代表性科研成果：

KeWang, Pei-Yin Liao, Cian-Ru Yang, Yu-Ting Su, Ping-ChingWu, Yang-Chang Wu, Yao-ChingHung,NajimAkhtar, Hsueh-Chou Lai* and Wen-Lung Ma*.Linoleate-PazopanibConjugation as Active Pharmacological Ingredient toAbolishesHepatocellular Carcinoma Growth.Frontiers in Pharmacology, 2024(DOI:10.3389/fphar.2023.1281067).

KeWang, Juan-Cheng Yang,Yeong-JiunnJang, Guan-Yu Chen,Ya-Jing Zhang, Yun-HaoDai, Da-Yong Zhang,*Yang-Chang Wu.* 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), anent-abietanediterpenediepoxide, inhibits the growth of bladder cancerT24cells through DNA damage.PlosOne,2021, 16(3): e0248468.

KeWang, Yang-Chang Wu, Juan-Cheng Yang,Meng-Han Zhang,Mohamed El-Shazly,Da-Yong Zhang,*Xiao-Ming Wu*. Synthesis of novel3,19-dihydroxyjolkinolides and related derivatives starting fromandrographolide.Synthesis-Stuttgart, 2016, 48, 2245-2254.

DanielWinardi, Pei-Yi Chu, Guan-Yu Chen,KeWang, Wei-Yu Hsu,Ching-Liang Hsieh,Yung-Hsiang Chen, Yang-Chang Wu,* and Juan-Cheng Yang*.Novel Aurora A Kinase InhibitorFangchinolineEnhancesCisplatin–DNA Adducts and Cisplatin Therapeutic Efficacy inOVCAR-3 Ovarian Cancer Cells-Derived Xenograft Model.Int. J. Mol. Sci.2022, 23, 1868.

Fen-Lan Wu, Pei-Yi Chu, Guan-Yu Chen,KeWang,Wei-Yu Hsu,AzajAhmed, Wen-Lung Ma, Wei-Chung Cheng, Yang-Chang Wu*, Juan-Cheng Yang*.NaturalAnthraquinoneCompoundEmodinas a Novel Inhibitor of Aurora A Kinase: a Pilot Study.Chemical Biology & Drug Design.2021.

Yan-ChengLiou, Yan-An Lin,KeWang, Juan-Cheng Yang,Yeong-JiunnJang*,WenweiLin, Yang-Chang Wu*.Synthesis ofnovelspiro-tetrahydroquinolinederivatives andevaluation oftheirpharmacologicaleffects onwoundhealing.Int. J. Mol. Sci.2021, 22(12), 6251.

Yan Luo,KeWang,Meng-HanZhang, Da-Yong Zhang,*Yang-Chang Wu,*Xiao-Ming Wu,Wei-Yi Hua. Synthesis of newent-labdanediterpenesderivatives fromandrographolideand evaluation of anticancer activity.Bio. Med. Chem. Lett., 2015, 25,2421-2424.

Chang-Zhen Zhu,KeWang,Meng-Han Zhang, Da-Yong Zhang,*Yang-Chang Wu,Xiao-Ming Wu,Wei-Yi Hua.Efficientsynthesis ofjolkinolidesA and B fromsteviol.Synthesis-Stuttgart, 2014, 46,2574-2578.

E-mail：waker603@njtech.edu.cn