汤丹丹，2020年毕业于浙江大学，获工学博士学位。毕业后进入山东大学微生物学博士后流动站工作，2024年2月进入新利18彩票 药学院。

研究方向：

1.利用合成生物学方法构建人工细胞工厂

2.新酶资源的挖掘分析及利用、工业生物催化

3.活性天然药物产物的生物合成、药物代谢及分析

主持科研项目：

1.主持国家自然科学基金青年基金32300023，2024-01-01～2026-12-31

2.主持青岛市博士后应用研究项目，2021-11-07～2023-11-7

代表性文章：

1.Tang DD,Liu W, Huang L, Cheng LM*, Xu ZN*. Efficient biotransformation of vitamin D₃to 25-Hydroxyvitamin D₃by a newly isolated strainBacillus cereus.Applied Microbiology and Biotechnology, 2020, 104(2): 765-774.

2.Tang DD,Shi F, Yang XL, Liu W, Zhao WJ, Qian RQ, Huang L, Cheng LM*, Xu ZN*. Enzymatic preparation and identification of 5’-adenosyl-methylthiopropylamine for the impurity control in SAM fermentation.Process Biochemistry, 2019, 87: 105-111.

3.Tang DD,Zheng XL, Zhao YS, Zhang CS, Chen C, Chen YX, Du L*, Liu K*, Li SY*. Engineered microbial consortium for de novo production of sclareolide.Journal of Agricultural and Food Chemistry, 2024.

4.Liu W, Tang DD, Shi R, Lian JZ*, Huang L, Cai J, Xu ZN*. Efficient production of S-adenosylL-methionine from DL-methionine in metabolic engineeredSaccharomyces cerevisiae.Biotechnology and Bioengineering, 2019,116(12): 3312-3323.

5.Liu W,Tang DD, Wang HJ, Lian JZ*, Huang L, Xu ZN*. Combined genome editing and transcriptional repression for metabolic pathway engineering inCorynebacterium glutamicumusing a catalytically active Cas12a.Applied Microbiology and Biotechnology, 2019,103(21): 8911-8922.

6.Li Ma, Fengwei Li, Xingwang Zhang, Hui Chen, Qian Huang, Jing Su, Xiaohui Liu, Tianjian Sun, Bo Fang, Kun Liu,DandanTang, Dalei Wu, Wei Zhang, Lei Du, Shengying Li*. Development of MEMS directed evolution strategy for multiplied throughput and convergent evolution of cytochrome P450 enzymes.Science China-Life Sciences. 2022,65,550-560.

7.Jiawei Guo, Fengwei Li, Fangyuan Cheng, Li Ma, Xiaohui Liu, Pradeepraj Durairaj, Gang Zhang,Dandan Tang, Xiangtian Long, Wei Zhang, Lei Du, Xingwang Zhang*, Shengying Li. Bacterial biosynthetic P450 enzyme PikCD50N: A potential biocatalyst for the preparation of human drug metabolites.The Journal of Organic Chemistry.2021,86,21,14563-14571.

8.Yuanyuan Jiang^#, Wei Peng^#, Zhong Li^#, Cai You, Yue Zhao,Dandan Tang, Binju Wang*, Shengying Li*. Unexpected reactions of α,β-unsaturated fatty acids provide insight into the mechanisms of CYP152 peroxygenases.Angewandte Chemie International Edition.2021,60,24694-24701.

9.Ruxin Liu, Yunjun Pan, Ning Wang,Dandan Tang, Vlada B.Urlacher, Shengying Li*. Comparative biochemical characterization of mammalian-derived CYP11A1s with cholesterol side-chain cleavage activities.The Journal of Steroid Biochemistry and Molecular Biology. 2023,229,106268.

10.Ke Bi, Wenguang Wang, Ni,Dandan Tang, Zhuwei Shi, Shuyu Tian, Lei Huang, Jiazhang Lian, Zhinan Xu*. Engineering sub-organelles of a diploidSaccharomyces cerevisiaeto enhance the production of 7-dehydrocholesterol.Metabolic Engineering. 2024,84,169-179.

联系方式：tangdandan924@163.com