周国春博士教授博士生导师
研究方向：药物化学，化学生物学
E-mail:gczhou@njtech.edu.cn
教育背景：
1997，9 - 2000，7博士中国科学院上海药物研究所
1986，9 - 1989，6硕士兰州大学化学系
1982，9 -1986，7本科南京大学 化学系
工作经历：
2010，3－现在,教授、课题负责人、博士生导师新利18彩票 药学院
研究方向：药物化学，化学生物学
2005，3－2010，3,研究员、课题组长(PI)、博士生导师中国科学院广州生物医药与健康研究院
研究方向：药物化学，化学生物学
2002，8–2005，2Research Associate美国爱因斯坦医学院生物化学系
2001，2–2002，8博士后美国 麻省理工学院(MIT)癌症研究中心和约翰霍普金斯大学医学院分子药理系
2000，8 - 2001，1博士后美国乔治城大学医学中心药物发现研究部
1989，6 - 1997，8助理工程师、工程师江苏省农药研究所
近期已发表和已接受的文章：
1.Yuran Peng, Jingjing Li, Yicheng Sun,Judy Yuet-Wa Chan, Dekuan Sheng, Kun Wang, Ping Wei, Pingkai Ouyang, Decai Wang,*Simon Ming Yuen Lee,*Guo-Chun Zhou*(周国春)“SAR studies of 3,14,19-derivatives of andrographolide on anti-proliferative activity to cancer cells and toxicity to zebrafish: an in vitro and in vivo study”RSC Adv., 2015,5, 22510 - 22526 (*共同通讯作者)
2.Z Liu, W-K Law, D Wang, X Nie, D Sheng, S Song, K Guo, P Wei, P Ouyang, C-W Wong*,Guo-Chun Zhou(周国春)*“Synthesis and discovery of andrographolide derivatives as non-steroidal farnesoid X receptor (FXR) antagonists”RSC Adv.,2014,4, 13533–13545 (*共同通讯作者)
3.Guo-Chun Zhou(周国春)*, Fang Liu, Junting Wan, Jing Wang*, Decai Wang, Ping Wei, Pingkai Ouyang“Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells”Eur J Med Chem2013,70, 631-639.(共同通讯作者)
4.Guo-Chun Zhou(周国春)*, Zhibing Weng, Xiaoxia Shao, Fang Liu, Xin Nie, Jinsong Liu, Decai Wang, Chunguang Wang, Kai Guo* “Discovery and SAR studies of methionine–proline anilides as dengue virus NS2B-NS3 protease inhibitors”,Bioorg Med Chem Lett2013,23, 6549–6554.(共同通讯作者)
5.Jing Wang, Shaopeng Chen, Hao Cheng, Fangyi Yang, Junting Wan, Jian Bo, Yingxue Liu,Junyun Yang,Jinsong Liu, andGuo-Chun Zhou“Identification, Structural Properties and Chelating Capacity of Miltipolone as a Broad-spectrum Growth Inhibitor to Cancer Cells”,Eur. J. Med. Chem.2011,46, 1117-1121.(通讯作者)
6.Qijun Liu, Hong Li, Shaopeng Chen,Guo-Chun Zhou“Synthesis of (3S,4R)-bengamide E”,Chin. Chem. Lett.,2011,22, 505–507..(通讯作者)
7.Huimin Cheng, Lianwen Zhang, Yingxue Liu, Shaopeng Chen, Hao Cheng,Xin Lu, Zhuxia Zheng,Guo-Chun Zhou“Design, Synthesis and Discovery of 5-Hydroxyaurone Derivatives as Growth Inhibitors against HUVEC and Some Cancer Cell Lines”,Eur. J. Med. Chem.,2010,45, 5950-5957.(通讯作者)
8.Hong Li, Yingxue Liu, Qijun Liu, Wenhui Hu,Guo-Chun Zhou“Asymmetric Synthesis of 2-Amino-5-Hydroxy-Caprolactam Derivatives Mediated byE-Selective Olefination and Asymmetric Oxidation of Enol Ether”,Synthesis,2010,23, 4068-4074.(通讯作者)
9.Fangyi Yang, Jie Wang, Hao Cheng, Junting Wan, Zhiyu Xiao,Guo-Chun Zhou“Amplificationin vitroof Unknown RNAs and RNA Mixtures Based on Unique Restriction Enzyme Cleavage”,Acta Biochim Biophys Sin,2010,42, 873-882.(通讯作者)
10.Xin Liu, Yingyong Ou, Shaopeng Chen,Xin Lu, Hao Cheng, Xian Jia, Decai Wang,Guo-Chun Zhou“Synthesis and inhibitory evaluation of cyclohexen-2-yl and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells”,Eur. J. Med. Chem.,2010,45, 2147-2153.(通讯作者)
11.Wenjuan Zhang, Jing Xu, Fang Liu, Chunfang Li, Yanling Jie, Shaopeng Chen, Zhiyuan Li, Jinsong Liu, Ling Chen,Guo-ChunZhou“Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A”,Chin J Chem,2010,28 (8), 1417-1423.(通讯作者)
12.Yuan Chen, Shaopeng Chen, Xin Lu, Hao Cheng, Yingyong Ou, Huimin Cheng,Guo-Chun Zhou“Synthesis, Discovery and Preliminary SAR Study of Benzofuran Derivatives as Angiogenesis Inhibitors”,Bioorg. Med. Chem. Lett.2009,19, 1851-1854.(通讯作者)
13.Zhang, L.; Yan, K.; Zhang, Y.; etal andGuochun Zhou“High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections”,Proc. Natl. Acad. Sci. USA2007,104,4606–4611.
14.Guo-Chun Zhou, Sapan L. Parikh, Peter C. Tyler, Gary B. Evans, Richard H. Furneaux, Olga V. Zubkova, Paul A. Benjes and Vern L. Schramm “Inhibitors of ADP-Ribosylating Bacterial Toxins Based on Oxacarbenium Ion Character at their Transition States ”,J Am Chem Soc.2004,126 (18), 5690-5698.
15.Guochun Zhou, Chiawei Tsai, Jun O. Liu “Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis”,J Med Chem.2003,46 (16), 3452-3454.
发明专利：
1．周国春杨方义成浩万军庭“用于RNA体外扩增的试剂及方法”申请号：200810219765.9，已授权。
2．周国春陈凌李志远陈绪林徐静李志远刘劲松“具有抑制和阻断M2离子通道活性的新化合物及其应用”申请号：200910137821.9，已授权。
3．周国春欧英勇刘昕陈少鹏陆鑫“具有抗肿瘤活性的新化合物及其应用”申请号：200910041814.9，已授权。
4．周国春杨俊芸刘英学陈少鹏刘劲松“ZXC-4A5或其药学上可接受的盐在制药中的新应用”申请号：200910194170.9，已授权。
5．周国春黄志伟刘竺云盛德宽聂鑫王德才“14-芳基醚穿心莲内酯衍生物及其制备方法和应用”申请号：201310146923.3，公开号：CN 103224492A
6．周国春翁智兵王春光邵晓霞聂鑫“二肽类似物的用途”申请号：201310354848.X，公开号：CN103585616A
7．周国春徐娟娟苏进财“5-羟基-2’-硝基橙酮或5-羟基-4’-硝基橙酮衍生物及其应用”申请号：201410222693.9
8．周国春翁智兵王德才“一种以巴卡丁III为原料制备卡巴他赛的方法”申请号：201410280836.1
9．周国春彭宇然李銘源李晶晶孙亦诚盛德宽聂鑫王德才“穿心莲內酯衍生物及其制备方法和应用”申请号：201410329264.1
10．周国春徐斌王德才“8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并氮杂卓的制备方法”申请号：201410380481.3
