当前位置: 网站首页> 师资队伍> 博士生导师> 正文
孙炳峰
阅读次数:发布时间:2023-05-24

孙炳峰,教授,博士生导师,药物化学教研室主任

致力于萜类、生物碱、大环内酯等复杂活性天然产物的基于新策略的高效全合成,完成了抗老年痴呆药物石杉碱甲(Huperzine A)、抗癌药物埃坡霉素(Epothilones B/D)、抗癌天然产物Englerin A/B、抗生素Platencin、复杂二萜Clavulactone20多个活性天然产物及类似物的全合成,其中石杉碱甲、埃坡霉素B/D的全合成效率迄今居于领先水平。近年来重视学术与应用相结合,将原子经济性步骤经济性氧化还原经济性以及绿色化学质量源于设计、“本质安全”等理念融入药物合成路线设计,成功开发抗凝药物利伐沙班(Rivaroxaban)、手性合成子长叶薄荷酮(Pulegone)等的创新绿色合成技术。

研究领域:

药物绿色高效合成,不对称合成,活性天然产物全合成,药物化学

教育研究经历:

2019年以来,新利18彩票 药学院,教授

2015-2017年,中科院上海有机化学研究所,研究员

2009-2015年,中科院上海有机化学研究所,副研究员

2005-2009年,美国印第安纳大学(Indiana University),布兰戴斯大学(Brandeis University),博士后

2000-2005年,中科院上海有机化学研究所,理学博士

1996-2000年,南京大学应用化学系,理学学士

获奖情况:

2018年,入选江苏省双创计划

2016年,荣获德国Thieme化学期刊奖

2016年,入选江苏省六大人才高峰

2012年,入选中科院青年创新促进会

近年主持和参与的部分项目:

1)国家自然科学基金委,面上项目22071108 “战略合成子的可放大合成及在药物合成中的应用

2)国家自然科学基金委,面上项目21672243 “Arteminolides的不对称全合成研究

3)国家自然科学基金委,面上项目21472210 “几个活性二萜类海洋天然产物的不对称全合成研究

4)国家自然科学基金委,面上项目21172246 “复杂二萜Vinigrol的全合成研究

5)国家自然科学基金委,青年基金20902101 “Englerin AEnglerin B的全合成研究

6)中国科学院青年创新促进会专项;

7)教育部留学回国人员科研启动基金;

8)科技部973项目2010CB833206 “全新方法和策略的天然产物全合成,参与;

9)国家自然科学基金委,重大研究计划具有重要药用价值的多环天然产物高效合成,参与。

近年发表论文目录:

1. Lin, X.; Li, N.; Zhu, C.; Sun, B.* “An Efficient Synthesis of Rivaroxaban”ChemistrySelect2023,8, e202204644.

2. Gu, Q.; Wang, X.; Sun, B.,* Lin, G. “Grob-Fragmentation Enabled Approach to Clavulactone Analogues”Org. Lett.2019,21, 5082-5085.

3. Hou, H.; Gu, Q.; Wang, X.; Sun, D.-Q.; Sun, B.-F.* “Organocatalytic Asymmetric Synthesis of Cornolactones A and B, and Formal Synthesis of Brasoside and Littoralisone”Org. Chem. Front.2018,5, 358-360.

4. Xu, G.-Q.; Lin, G.-Q.; Sun, B.-F.* “Concise Asymmetric Total Synthesis of (−)-Patchouli Alcohol”Org. Chem. Front.2017,4, 2031-2033.

5. Wang, X.; Sun, W.-B.; Zou, J.-P.; Lin, G.-Q.; Sun, B.-F.* “Asymmetric Total Synthesis of Hedyosumin E aglycon, 7,10-Epoxyhedyosminolide andent-Zedolactone A”Org. Biomol. Chem.2016,14, 10581-10584.

6. Liu, L.; Zhou, S.;* Sun, B.* “Progresses in Total Synthesis of Platencin”Chin. J. Org. Chem.2016,36, 2091-2104.(review, in Chinese)

7. Fu, J.-G.; Shan, Y.-F.; Sun, W.-B.; Lin, G.-Q.; Sun, B.-F.* “An asymmetric approach to bicyclo[2.2.1]heptane-1-carboxylates via a formal [4+2] cycloaddition reaction enabled by organocatalysis”Org. Biomol. Chem.2016,14, 5229-32.

8. Sun, W.-B.; Wang, X.; Sun, B.-F.;* Zou, J.-P.; Lin, G.-Q. “Catalytic Asymmetric Total Synthesis of Hedyosumins A, B, and C”Org. Lett.2016,18, 1219-1221.

9. Fu, J.-G.; Xu, G.-Q.; Ding, R.; Lin, G.-Q.; Sun, B.-F.* “Asymmetric Total Synthesis of Lycopodium Alkaloids α-Obscurine,N-Desmethyl-α-obscurine, β-Obscurine and N-Desmethyl-β-obscurin”Org. Chem. Front.2016,3, 62-65.

10. Liu, J.; Zheng, H.-X.; Yao, C.-Z.; Sun, B.-F.; Kang, Y.-B.* “Pharmaceutical-Oriented Selective Synthesis of Mononitriles and Dinitriles Directly from Methyl(hetero)arenes: Access to Chiral Nitriles and Citalopram”J. Am. Chem. Soc.2016,138, 3294-3297.

11. Wang, J.; Sun, W.-B.; Li, Y.-Z.; Wang, X.; Sun, B.-F.*; Lin, G.-Q.; Zou, J.-P. “A Concise Formal Synthesis of PlatencinOrg. Chem. Front.2015,2, 674-676.

12. Sun, B.-F.* “Total Synthesis of Natural and Pharmaceutical Products Powered by Organocatalytic Reactions”Tetrahedron Letters,2015,56, 2133-2140.

13. Li, Y.-Z.; Wang, J.; Sun, W.-B.; Shan, Y.-F.; Sun, B.-F.*; Lin, G.-Q.*; Zou, J.-P. “Enantioselective Synthesis of Bicyclo[2.2.2]octane-1-carboxylates under Metal Free Conditions”Org. Chem. Front.2015,2, 274-278.

14. Fu, J.-G.; Ding, R.; Sun, B.-F.*; Lin, G.-Q.* “Wagner-Meerwein Rearrangement of[3.3.1] BicyclicN-Boc Aminols: Vinyl Migration in Preference to Aryl Migration”Tetrahedron2014,70, 8374-8379.

15.Wang, X.-L.; Lu, Y.-Y.; Wang, J.; Wang, X.; Yao, H.-Q.; Lin, G.-Q.; Sun, B.-F.* “A Novel Synthetic Approach to the Bicyclo[5.3.1]undecan-11-one Framework of Vinigrol”Org. Biomol. Chem.2014,12, 3562-3566.(cover)

16. Ding, R.; Fu, J.-G.; Xu, G.-Q.; Sun, B.-F.*; Lin, G.-Q.* “Divergent Total Synthesis ofLycopodiumAlkaloidsHuperzine A, Huperzine B and Huperzine U”J. Org. Chem.2014,79, 240-250.

17.Wang, J.; Chen, S.-G.; Sun, B.-F.*; Lin, G.-Q.*; Shang, Y.-J. “Collective Total Synthesis of Englerin A, Englerin B, Orientalol E, Orientalol F, and Oxyphyllol: Application of the Organocatalytic [4+3] Cycloaddition Reaction”Chem. Eur. J.2013,19, 2539-2547.

18. Wang, J.; Sun, B.-F.*; Cui, K.; Lin, G.-Q.* “An Efficient Total Synthesis of (-)-Epothilone B”Org. Lett.2012,14, 6354.

19. Ding, R.; Sun, B.-F.*; Lin, G.-Q.* “An Efficient Total Synthesis of (-)-Huperzine A”Org. Lett.2012,14, 4446-4449.

著作章节:

1.Strategies and Tactics in Organic Synthesis, ISBN: 9780128117903ed. Michael Harmata, 2017Vol 13, Chapter 6: Total synthesis of guaianoids through a strategy powered by organocatalytic [4+3] cycloaddition reactions.

2.《天然产物全合成荟萃——抗生素及其他》吴毓林等,2012年,第十章 埃坡霉素的全合成综述。

E-mail:bfsun@njtech.edu.cn


Baidu