姓名：张 琪
职称：教授，博士生导师
职务：药学院 党委副书记；
新利18彩票 药动药效研究与评价中心 主任
学术兼职：
江苏省高校医药教育研究会副理事长；
江苏省药理学会常务理事；
药学核心期刊《中国临床药理学与治疗学》、《中华男科学杂志》编委
江苏省食品药品监督管理局新药审评与现场核查专家
教育简历：
美国纽约州立大学布法罗分校（State University of New York at Buffalo）博士后；
中国药科大学药理学博士。
研究领域：药理学、药物动力学、代谢组学。
在基础研究领域着重于各类新药的临床前与临床的药物动力学、药效学筛选、药理学机制靶点、药效-药动学模型研究，以及骨质疏松症、高脂血症等重大疾病的代谢组学研究。尤其是代谢组学方法学及其应用的研究成果处于国内外前列。
近年来承担国家自然科学基金面上项目5项（主持3项，联合单位负责人2项）；国际合作项目2项（美国纽约州立大学、美国FDA-马里兰大学）；国家973预研项目1项；省基金1项（抗骨质疏松一类新药的临床前研究）；省临床医学专项1项（骨质疏松生物标记物研究）；参与国家973、省部科研项目8项。申请专利8项（2项授权）。发表学术文章约80篇（46篇被SCI收录）；参与编写英文论著1部，中文著作、化工辞典各1部。
主持建立了“新利18彩票 药动药效研究与评价中心”，中心拥有药物分析、药效评价、分子生物学、细胞培养、动物实验等技术平台，按照国家食品药品监督管理局颁布的“药物临床试验生物样本分析实验室管理指南”的要求进行建设、管理和运行。有资质从事新药药学、临床前药物动力学、药理学以及临床药物动力学（生物等效性实验）检测部分的研究与新药报批工作。
近年来，与上海第二军医大学、山东鲁抗集团、无锡凯夫药业、南京白敬宇制药公司等十几个医药科研/企业单位合作，主持了碱性成纤维细胞生长因子、黄芪甲苷、磷酸二果糖锶等一类新药的药理学、药动学研究及Etanercept、银杏提取物、硝苯地平缓释片、阿斯匹林缓释片等50多种新药的药理学、药物动力学、生物等效性研究，新药资料全部通过省局现场核查。
所获荣誉：
江苏省“333高层次人才培养工程”培养对象
江苏省“六大人才高峰”培养对象
南京市“321”领军型科技创业人才
新利18彩票 首届“工大才俊”高层次人才培养对象
讲授课程：
药理学、药物动力学（本科生课程）；现代药理学（研究生课程）
科研成果：
参与编写的中英文论著：
英文论著：《Strontium: Chemical Properties, Applications and Health Effects》一书中的第一章节“The Effects of Strontium on Physiology, Pharmacology and Toxicity of the Human” 出版社：NOVA Publishers 出版日期：2013年 ISBN：978-1-62257-631-9
中文论著：《10000个科学难题（医学卷）》， “药动学-药效学结合模型—连接体内药物浓度与药效关系的桥梁”，科学出版社，2011年8月正式出版，P955-958。 “十一五”国家重点图书出版规划项目
辞典：《化工辞典（第五版）》，化学工业出版社，2014年5月
近年来以第一作者或通讯作者发表的SCI文章：
1.Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy. Journal of Materials Chemistry B, 2016,4 (1) :113-120
2.Diketopyrrolopyrrole Derivatives Grafting Hyaluronic Acid for Targeted Photodynamic Therapy, Chemistryselect, 2016, 1, 3071-3074
3.Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy, ACS Applied Materials & Interfaces, 2016, 8, 10737-10742
4.Association between the metabolome and bone mineral density in pre- and post-menopausal Chinese women using GC-MS. Molecular BioSystems, 2016，12（7）：2265-2275
5.Wnt/b-catenin signaling plays an important role in the protective effects of FDP-Sr against oxidative stress induced apoptosis in MC3T3-E1 cell. Bioorganic & Medicinal Chemistry Letters. 2016 (26): 4720-4723
6. Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study. Toxicology ,
2015；336:84-95.
7.Strontium fructose 1, 6-diphosphate- alleviate cyclophosphamide induced – oligozoospermia by improving antioxidant and inhibiting androgone apoptosis via FSA/FASL pathway. Andrologia，2015 ,47（9: 995-1003
8. Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC-ESI-MS/MS assay. Journal of Chromatography B, 2015, 1002:245-253.
9.A pre-clinical pharmacokinetic study inratsofthreenaturally occurring iridoidglycosides, Picroside-I, IIandIII,using a validated simultaneous HPLC – MS/ MS assay, J.Chromatogr.B，2015, 993-994：47–59
10.Quantitative ananlysis of tenuifolin concentrations in rat plasma and tissue using LC-MS/MS: application to pharmacokinetic and tissue distribution study. Journal of Pharmaceutical and Biomedical Analysis, 88(2014): 191-200.
11.Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography–tandem mass spectrometry；Journal of Chromatography B，970（2014）：77-85
12.Metabolomic analysis of simvastatin and fenofibrate in high - lipid diet - induced hyperlipidemia rats. Acta Pharmacologica Sinica, 2014, 33(4): 479-489 IF: 2.35
13. Comparative pharmacokinetics with single substances and Semen Cuscutae extract after oral administration and intravenous administration Semen Cuscutae and single hyperosede and astragalin to rats. Analytical Methods. 2014, 6, 7250–7259.
14.Metabolomic Profiles Delineate Signature Metabolic Shifts during Estrogen Deficiency-Induced Bone Loss in Rat by GC-TOF/MS. PLOS ONE, 2013,8(2):e54965.
15 Simultaneous determination of Eleutheroside B and Eleutheroside E in rat plasma by high performance liquid chromatography-electrospray ionization mass spectrometry and its application in a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci, 2013, 917-918 : 84-92.
16.Rapid analysis of tadalafil in human blood plasma and seminal plasma by liquid chromatography/tandem mass spectrometry. J Pharm Biomed Anal, 2013,77C :149-157.
17.Simultaneous determination of oridonin, ponicidin and rosmarinic acid from Herba Isodi Rubescentis extract by LC-MS-MS in rat plasma. Journal of chromatographic science, 2013, 51 (10): 910-8.
18.Development and validation of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of raddeanin A in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci, 2013,912:16-23.
19.Expression and distribution of Attractin related changes in the different developmental stages of rats testis. International Journal of Molecular Medicine, 2013 32(3): 599-606.
20.Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1, 6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS European Journal of Pharmacology, 718(2013)：524-532.
21. Strontium fructose 1, 6-fiphosphate (FDP-Sr) treatment prevents bone loss in a rat model of postmenopausal osteoporosis via OPG\RANKL\RANK pathway. Acta Pharmacologica Sinica, 2012, 33(4): 479-489
22.GC-TOF/MS-based metabolomic proiling of estrogen deiciency-induced obesity in ovariectomized rats. Acta Pharmacologica Sinica , 2011(32): 270-278
23. Synthesis and pharmacokinetics of strontium fructose 1,6-diphosphate (Sr-FDP) as a potential anti-osteoporosis agent in intact and ovariectomized rats. J Inorg Biochem, 2011,105(4):563-568.
24.Metabonomic profiling of diet-induced hyperlipidaemia in a rat model.Biomarkers 2010 May;15(3):205-16.
25.Strontium fructose 1,6- diphosphate alleviates early diabetic testopathy by suppressing abnormal testicular matrix metallop- roteinase system in streptozocin-treated rats [J]. J Pharmacy Pharmacology, 2009, 61: 229-236
26.(2-Pyridyl)acetone-Promoted Cu-Catalyzed O- Arylation of Phenols with Aryl Iodides, Bromides, and Chlorides. The Journal of Organic Chemistry, 2009, 74:7187–7190
27. Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats. Acta Pharmacologica Sinica, 2009, 30(12):1674-1687
